0102030405
Sh-Pentapeptide-1 Advanced Skin Barrier Repair & Cellular Renewal
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Product Description
1. MOA
Sh-Pentapeptide-1 is an innovative thiol-modified peptide engineered to enhance skin barrier function and accelerate cellular recovery through advanced biochemical mechanisms.
Thiol-Mediated Cellular Uptake:
The sulfhydryl (SH) group enables enhanced membrane permeability through thiol-disulfide exchange reactions with cell surface proteins
Facilitates rapid intracellular delivery of the bioactive peptide sequence
Increases bioavailability compared to conventional peptides
Nrf2/ARE Pathway Activation:
Activates the Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway
Enhances expression of antioxidant response element (ARE)-regulated genes
Upregulates production of endogenous antioxidants (glutathione, superoxide dismutase)
Barrier Protein Synthesis:
Stimulates synthesis of key barrier components including filaggrin, involucrin, and loricrin
Promotes lamellar body secretion and lipid reorganization in stratum corneum
Enhances tight junction protein assembly (claudin-1, occludin)
2. In Vitro Efficacy Data
In-vitro studies demonstrate superior barrier enhancement capabilities:
Gene Expression Analysis:
3.2-fold increase in filaggrin expression
2.8-fold upregulation of loricrin
4.1-fold enhancement of antioxidant enzyme genes
Cellular Uptake Studies:
68% higher cellular internalization vs. non-thiolated peptide
Sustained intracellular presence for 24+ hours
Barrier Function Models:
45% reduction in transepidermal water loss (TEWL) in reconstructed epidermis
52% improvement in barrier recovery rate
3. Clinical Results
8-week clinical study with 42 subjects exhibiting compromised skin barrier:
Barrier Function:
39% reduction in TEWL
47% improvement in barrier recovery
34% increase in stratum corneum hydration
Clinical Assessment:
78% reduction in dryness scores
65% improvement in roughness
71% decrease in scaling
Sensory Evaluation:
89% reported immediate relief from tightness
94% noted improved skin comfort
82% observed reduced reactivity
Safety Profile
*Non-irritating (0/30 subjects in HRIPT)
*Non-sensitizing *Suitable for compromised skin
*Non-sensitizing *Suitable for compromised skin
Formulation Compatibility
PH Range: 5.0-7.0 (optimal stability) Temperature Stability: Maintains activity after 3 months at 45°C
Synergistic Combinations
Ceramides & Cholesterol Niacinamide
Hyaluronic Acid
Panthenol
Hyaluronic Acid
Panthenol
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Recommended Usage & Dosage
Usage Level: 2-5% in final formulation
Recommended Formulations:
Barrier repair creams
Sensitive skin treatments
Post-procedure recovery products
Medical skincare formulations
Intensive rescue serums
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Advanced Delivery Technology
Thiol modification enables superior cellular uptake and bioavailability
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Multi-Target Barrier Repair
Addresses barrier function at molecular, cellular, and structural levels
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Clinically Proven Efficacy
Significant improvement in barrier parameters and skin comfort
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Antioxidant Protection
Activates endogenous defense systems against oxidative stress
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available